Tramadol is marketed as ultram. It is an opioid medicine mainly helpful in moderate and severe pain. When it is taken as immediate release oral forms, the pain relief onset is within an hour. It has 2 varying mechanisms. First, Tramadol 50mg gets attached to opioid receptors and secondly it inhibits the re-uptake of nor epinephrine or serotonin.
Medical Uses:
Tramadol is used for pain management in case of fibromyalgia. It has analgesic effect and normally takes 1 hour to come into effect and two to four hours to reach the peak after administered orally in case of immediate release formulation. Tramadol 100mghas one tenth potency of morphine when on a dose by dose criteria. It is equally potent when it is compared to codeine or pethidine. For moderate pain it is equivalent to morphine and in case of severe pains it less effective than morphine. After post oral administration pain killing effects reaches to peak in three hours and lasts for about six hours. Such analgesic effects can be partially reversed by naloxone. It is similar to tapentadol and levorphanol pharmacologically as it binds to mu opioid receptors. The available forms of tramadol are capsules, tablets including both injections and extended release formulation. Buy Tramadol online to treat mild-severe pain both acute as well as chronic.
Adverse effects
Most common side effects include:
Vomiting
Dry mouth
Constipation
Vertigo
Headache
Drowsiness
Nausea
Abdominal pain
When compared to other opioids constipation and respiratory depression is less of a problem.
Serious adverse effects
The serious side effects are increased risk of suicide, seizures, serotonin syndrome, drug addiction or decreased alertness. Kidney or liver patients may be prescribed a changed dosage. Breastfeeding women are not recommended this medication. It is commonly marketed as racemic mixture of S and R stereoisomer. The reason is that the 2 isomers compliment each of their analgesic activity. To improve the efficacy of pain it is sometimes combined with paracetamol. Tramadol is metabolized into O-desmethyltramadol (potent opioid). By German pharmaceutical it was launched and marketed as Tramal.
Drug interactions
Avoid taking following drugs with tramadol as it can cause dangerous effects in the body.
Carbmazepine: If it is taken with tramadol, the tramdol effect becomes lesser in relieving from pain. It decreases the tramadol in the body making more prone to seizures.
Depression drugs: Your serotonin level will increase if you take anti-depressants along with tramadol. Symptoms include restlessness, nausea, vomiting, fast heart beat or increased body temperature.
Order Tramadol online and ensure to adjust your dosage if you are taking other drugs by taking advice from health care professional.
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